- Diagnostic proficiency test using digital cytopathology and comparative assessment of whole slide images of cytologic samples for quality assurance program in Korea
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Yosep Chong, Soon Auck Hong, Hoon Kyu Oh, Soo Jin Jung, Bo-Sung Kim, Ji Yun Jeong, Ho-Chang Lee, Gyungyub Gong
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J Pathol Transl Med. 2023;57(5):251-264. Published online August 24, 2023
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DOI: https://doi.org/10.4132/jptm.2023.07.17
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 Abstract
 PDF Supplementary Material
- Background
The Korean Society for Cytopathology introduced a digital proficiency test (PT) in 2021. However, many doubtful opinions remain on whether digitally scanned images can satisfactorily present subtle differences in the nuclear features and chromatin patterns of cytological samples.
Methods
We prepared 30 whole-slide images (WSIs) from the conventional PT archive by a selection process for digital PT. Digital and conventional PT were performed in parallel for volunteer institutes, and the results were compared using feedback. To assess the quality of cytological assessment WSIs, 12 slides were collected and scanned using five different scanners, with four cytopathologists evaluating image quality through a questionnaire.
Results
Among the 215 institutes, 108 and 107 participated in glass and digital PT, respectively. No significant difference was noted in category C (major discordance), although the number of discordant cases was slightly higher in the digital PT group. Leica, 3DHistech Pannoramic 250 Flash, and Hamamatsu NanoZoomer 360 systems showed comparable results in terms of image quality, feature presentation, and error rates for most cytological samples. Overall satisfaction was observed with the general convenience and image quality of digital PT.
Conclusions
As three-dimensional clusters are common and nuclear/chromatin features are critical for cytological interpretation, careful selection of scanners and optimal conditions are mandatory for the successful establishment of digital quality assurance programs in cytology.
- Sebaceous Carcinoma Arising in Mature Cystic Teratoma of Ovary
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Hyo Jeong An, Yong Han Jung, Hye Kyoung Yoon, Soo Jin Jung
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Korean J Pathol. 2013;47(4):383-387. Published online August 26, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.383
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Abstract
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Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports. -
Citations
Citations to this article as recorded by  - Extraocular sebaceous carcinoma arising in a mature cystic teratoma of ovary: A case report and review of literature
Sara Pakbaz, Tanya Chawla, Marcus Q Bernardini, Liat Hogen, Marjan Rouzbahman
Human Pathology Reports.2022; 27: 300592. CrossRef - Sebaceous adenoma occurring within an intracranial dermoid cyst
Takashi Minamisaka, Johji Imura, Keitaro Shiraishi, Kohji Takagi, Takahiko Tomia, Sinichi Tanaka, Akira Noguchi, Takuya Akai, Kyo Noguchi, Satoshi Kuroda
Neuropathology.2022; 42(4): 289. CrossRef - Malignant transformation of mature cystic teratoma of the ovary
Doaa Atwi, Maria Kamal, Michael Quinton, Lewis A. Hassell
Journal of Obstetrics and Gynaecology Research.2022; 48(12): 3068. CrossRef - Sebaceous Carcinoma Arising in Ovarian Teratoma: First Report Associated With Germline Mismatch Repair Gene Mutation
Jacinta Murray, Patrick McIlwaine, Patrick J. Morrison, W. Glenn McCluggage
International Journal of Gynecological Pathology.2022; 41(6): 608. CrossRef - Impact of surgery and adjuvant treatment on the outcome of extraocular sebaceous carcinoma: a systematic review and individual patient's data analysis of 206 cases
Prashanth Giridhar, Lakhan Kashyap, Supriya Mallick, Ashish Dutt Upadhyay, Goura K. Rath
International Journal of Dermatology.2020; 59(4): 494. CrossRef - Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma
Alvin Ho-Kwan Cheung, Chit Chow, Mei-Yung Yu, Wendy Wai-Tak Law, Peggy Pui-Ying Law, Paul Cheung-Lung Choi, Wei Kang, Ka-Fai To
Pathology.2019; 51(1): 67. CrossRef - Malignant transformation of an ovary mature cystic teratoma: case report and review of the literature
Elkin Fabián Dorado-Roncancio, Oscar Joel Carrillo-Garibaldi
Obstetrics & Gynecology International Journal.2019;[Epub] CrossRef - A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma
Kazuya Maeda, Yoshito Terai, Shinichi Terada, Hiroshi Maruoka, Yuhei Kogata, Keisuke Ashihara, Yoshimichi Tanaka, Tomohito Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Takashi Yamada, Masahide Ohmichi
Journal of Ovarian Research.2018;[Epub] CrossRef - Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J. Li, Shivani Kandukuri
Gynecologic Oncology Reports.2018; 26: 37. CrossRef
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